Inappropriate Antimicrobial Dosing in Regard to Renal Function in a Tertiary Hospital in Greece—A Single-Center Point Prevalence Study

: Inappropriate antimicrobial dosing based on kidney function remains common in hospitalized patients, particularly among older individuals and those with impaired renal function or polypharmacy. Targeted antimicrobial stewardship strategies focusing on renal dose adjustment and agents that are more frequently dosed inappropriately, such as colistin, acyclovir, cefuroxime, and ceftazidime, as well as agents that are frequently prescribed despite a relatively lower rate of inappropriate dose, such as piperacillin/tazobactam, are needed to enhance prescribing safety and optimize therapeutic outcomes.

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Publication Details

Journal
Medicina
Published
2026-04-13
DOI
https://doi.org/10.3390/medicina62040743
Primary Topic
Antibiotics Pharmacokinetics and Efficacy
Type
article
Field-Weighted Citation Impact
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article

Inappropriate Antimicrobial Dosing in Regard to Renal Function in a Tertiary Hospital in Greece—A Single-Center Point Prevalence Study

Andria Papazachariou, Stamatis Karakonstantis, Πέτρος Ιωάννου, Diamantis P. Kofteridis
Medicina
Antibiotics Pharmacokinetics and Efficacy
article

Inappropriate Antimicrobial Dosing in Regard to Renal Function in a Tertiary Hospital in Greece—A Single-Center Point Prevalence Study

Andria Papazachariou, Stamatis Karakonstantis, Πέτρος Ιωάννου, Diamantis P. Kofteridis
article en

Abstract

: Inappropriate antimicrobial dosing based on kidney function remains common in hospitalized patients, particularly among older individuals and those with impaired renal function or polypharmacy. Targeted antimicrobial stewardship strategies focusing on renal dose adjustment and agents that are more frequently dosed inappropriately, such as colistin, acyclovir, cefuroxime, and ceftazidime, as well as agents that are frequently prescribed despite a relatively lower rate of inappropriate dose, such as piperacillin/tazobactam, are needed to enhance prescribing safety and optimize therapeutic outcomes.

MedicinaVol. 62(4)
University of Crete (GR), University Hospital of Heraklion (GR)
Good health and well-being
Openalex Percentile: Top 27%
Antibiotics Pharmacokinetics and Efficacy
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Inappropriate Antimicrobial Dosing in Regard to Renal Function in a Tertiary Hospital in Greece—A Single-Center Point Prevalence Study — Andria Papazachariou, Stamatis Karakonstantis, et al. · Medicina (2026) | TGRS Research Map | TGRS