Self-Assembling Enveloped Virus-Mimicking Particle for Extrahepatic Targeting mRNA Delivery

key assembling domain mutation, strategic N-terminal fatty acylation modifications, and precise adjustments to envelope phospholipid composition, we achieved high-efficiency delivery of mRNA to organs such as the lungs and spleen. Notably, the optimized lung-targeted EVMP achieved transfection in 37% of total lung cells, including 73% of endothelial cells and 28% of immune cells. In a metastatic lung tumor model, the lead EVMP loaded with IL-12 mRNA effectively suppressed tumor progression. Notably, EVMP demonstrated excellent long-term biosafety and the capacity for repeated administration, owing to their minimal immunogenic profile. This biomimetic virus-mimicking nanoplatform represents a transformative advance in mRNA delivery technologies, enabling effective and safe mRNA-based therapy for extrahepatic diseases. Furthermore, it establishes a generalizable strategy for bottom-up engineering of biomimetic materials with programmable tissue tropism and modular functionality.

Authors

Institutions

Publication Details

Journal
ACS Nano
Published
2026-04-13
DOI
https://doi.org/10.1021/acsnano.5c21254
Primary Topic
RNA Interference and Gene Delivery
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Self-Assembling Enveloped Virus-Mimicking Particle for Extrahepatic Targeting mRNA Delivery

Renhe Yu, Antian Wang, Sheng‐Tao Yu, Wen Shi et al.
ACS Nano
RNA Interference and Gene Delivery
article

Self-Assembling Enveloped Virus-Mimicking Particle for Extrahepatic Targeting mRNA Delivery

Renhe Yu, Antian Wang, Sheng‐Tao Yu, Wen Shi, Yukun Huang, Gan Jiang, Xinkai Nie, Xiaoling Gao, Jingfa Zhang, Qingxiang Song, Chenyun Zhang, Lin Chen, Yaoxing Chen, Peiying Li, Kexin Shi, Chen Fan
article en

Abstract

key assembling domain mutation, strategic N-terminal fatty acylation modifications, and precise adjustments to envelope phospholipid composition, we achieved high-efficiency delivery of mRNA to organs such as the lungs and spleen. Notably, the optimized lung-targeted EVMP achieved transfection in 37% of total lung cells, including 73% of endothelial cells and 28% of immune cells. In a metastatic lung tumor model, the lead EVMP loaded with IL-12 mRNA effectively suppressed tumor progression. Notably, EVMP demonstrated excellent long-term biosafety and the capacity for repeated administration, owing to their minimal immunogenic profile. This biomimetic virus-mimicking nanoplatform represents a transformative advance in mRNA delivery technologies, enabling effective and safe mRNA-based therapy for extrahepatic diseases. Furthermore, it establishes a generalizable strategy for bottom-up engineering of biomimetic materials with programmable tissue tropism and modular functionality.

ACS NanoVol. 20(16)
Shanghai Jiao Tong University (CN), Chinese University of Hong Kong, Shenzhen (CN), Shanghai First People's Hospital (CN), Massachusetts Eye Research and Surgery Institute (US), He Eye Hospital (CN), Shanghai Universities E-Institute for Chemical Biology (CN)
Innovative Research Team of High-level Local University in Shanghai, Shanghai Science and Technology Development Foundation, National Natural Science Foundation of China, China Postdoctoral Science Foundation, Shanghai Municipal Education Commission, National Key Research and Development Program of China
Openalex Percentile: Top 20%
RNA Interference and Gene Delivery
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.