A Molecular Imaging Strategy for In Vivo Monitoring of Vascular Remodeling in a Porcine Model of Femoral Artery Overdilation
PURPOSE: F)-fluorodeoxyglucose (FDG) for in vivo detection of peripheral angioplasty-induced arterial remodeling. METHODS: F-FDG uptake) and stained with hematoxylin and eosin (H&E), alpha-smooth muscle actin (α-SMA), and CD64 for evaluation of arterial thickness, smooth muscle cell area, and macrophage infiltration. RESULTS: F-FDG uptake. CONCLUSION: F-FDG PET/CT quantifies remodeling characteristics associated with angioplasty-induced injury, thereby providing a potential in vivo paradigm for monitoring and testing of emerging devices for PAD treatment.
Authors
- Kumudha Narayana Musini
- Mahboubeh Nabavinia (ORCID: https://orcid.org/0000-0003-1359-0671)
- Mitchel R. Stacy (ORCID: https://orcid.org/0000-0002-8423-1011)
- Corrin Mansfield (ORCID: https://orcid.org/0000-0002-1712-307X)
- Michael R. Go (ORCID: https://orcid.org/0000-0002-8256-893X)
- Anjana Jayaraman (ORCID: https://orcid.org/0000-0001-7372-2352)
- Eleanor T. Rimmerman (ORCID: https://orcid.org/0000-0001-7405-523X)
- Katherine E. Mevis
Institutions
- Nationwide Children's Hospital (US)
- The Ohio State University (US)
Publication Details
- Journal
- Annals of Biomedical Engineering
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1007/s10439-026-04141-6
- Primary Topic
- Peripheral Artery Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute