Antimicrobial efficacy of carbon nanotube-based nano drug on Escherichia coli and expression of Acr AB gene involved in bacterial drug resistance

Background: has been known as the main agent involved in urinary tract infections, and Ampicillin (AMP) is usually prescribed for the treatment of this infection. Due to the development of antibiotic resistance as a result of consuming conventional antibiotics, modification of pure drugs has been recommended as a solution to this problem. The main purpose of this study is to prepare AMP-conjugated nanofluids containing carbon nanotubes for enhanced drug performance as well as the prevention of antibiotic resistance. Methods: resistance gene expression has been assessed. Result: gene expression decreases in bacteria treated with AMP-MWCNT. Conclusion: gene expression was found to be decreased in bacteria treated with AMP-MWCNT.