Increased Constitutive Interferon‐β Levels and Altered CD4 T Cell Homeostasis Induced by Expression of a Viral Glycoprotein
memory-phenotype CD4 T cells and regulatory CD4 T cell populations were enlarged in these LCMV GP-tg mice; by contrast, the fraction of bona fide antigen-specific memory CD4 T cells remained unchanged. Our study demonstrates that expression of a single viral envelope gene increased constitutive IFN-β levels, induced upregulation of ISGs, and altered CD4 T cell homeostasis. Our results further suggest that a hitherto undefined signaling pathway capable of inducing IFN-β expression can detect LCMV GP at the protein or transcript level.
Authors
- Annette Oxenius (ORCID: https://orcid.org/0000-0002-2079-2354)
- Oliver S. Thomas (ORCID: https://orcid.org/0000-0003-1949-0938)
- Anne Haefke (ORCID: https://orcid.org/0000-0001-6235-9658)
- Thomas Boehm
- Hanspeter Pircher
Institutions
- University Medical Center Freiburg (DE)
- ETH Zurich (CH)
- Max Planck Institute of Immunobiology and Epigenetics (DE)
- Max Planck Institute for Biology (DE)
Publication Details
- Journal
- European Journal of Immunology
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/eji.70188
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 11.92
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Max-Planck-Gesellschaft
- National Institutes of Health