Characterizing juvenile-onset systemic lupus erythematosus: clinical outcomes, disease progression, and determinants in pediatric populations.

This study found that jSLE mainly affects female patients, with musculoskeletal, renal, and hematologic involvement being the most common manifestations. Renal involvement is associated with initial anti-dsDNA positivity and SLEDAI-2K scores. The study also found that better remission outcomes are linked to lower initial disease activity and longer follow-up periods.