Rhodium-Catalyzed Desymmetric Addition of Boronic Acids to Malononitriles
)-C(α) bond rotation of complexed nitrile and thus enforces precise substrate orientation. Consequently, β-ketonitriles bearing a quaternary stereocenter are obtained in good enantiopurity with versatile reactivity arising from the remaining nitrile, the newly generated ketone, and diverse substituents retained from the malononitrile reactant.
Authors
- Jun Wang (ORCID: https://orcid.org/0000-0001-9723-4054)
- Zhongxing Huang (ORCID: https://orcid.org/0000-0003-0196-3469)
- Qiang Zhang (ORCID: https://orcid.org/0000-0001-6662-1668)
- Junjie Cao
- Jianchun Wang (ORCID: https://orcid.org/0000-0002-3998-8699)
- Minghao Zhang
Institutions
- Hong Kong Baptist University (HK)
- Southern University of Science and Technology (CN)
- State Key Laboratory of Synthetic Chemistry (CN)
- Advanced Research Institute (US)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2026-04-12
- DOI
- https://doi.org/10.1021/jacs.5c23045
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Research Grants Council, University Grants Committee
- Innovation and Technology Commission