Bergamottin pretreatment attenuates cisplatin-induced acute kidney injury in mice by inhibiting BACE-1-mediated ferroptosis
substantially abolished the protective effect of BGM on HK-2 cells that received cisplatin. BGM effectively alleviated AKI by targeting BACE-1 to reduce ferroptosis, suggesting that BGM could be developed as a potential agent for managing and pretreating AKI.
Authors
- Yajie Wang (ORCID: https://orcid.org/0000-0001-7259-3886)
- You-song Xu
- Hui-feng Yuan
- Song Peng
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Third People's Hospital of Hefei (CN)
Publication Details
- Journal
- Renal Failure
- Published
- 2026-04-12
- DOI
- https://doi.org/10.1080/0886022x.2026.2641847
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00