Curcumin: Promising Modulator of Hypoxia Signaling in Cancer

Solid tumors are widely known for having hypoxia, which promotes the growth and metastasis of the tumor. It is crucial for research and medicine to comprehend the diverse strategies by which cells sense oxygen and preserve oxygen homeostasis. A rising number of drugs have been found to block hypoxia function through various molecular pathways. For instance, curcumin, a naturally occurring polyphenolic chemical, has the ability to alter the tumor microenvironment and significantly influence the course of malignancy. Studies revealed that curcumin inhibits the signaling pathways including PI3K/Akt, AMPK-mTOR, and NF-κB, which are key factors in preventing hypoxia-induced cancer spread. In this article, we have discussed about the potential use of curcumin as a promising inhibitor of the molecular targets essential for hypoxia cell survival. Therefore, curcumin with strong anticancer effects could work well as a tumor-static drug in chemoprevention by inactivating hypoxia.

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Journal
Journal of Biochemical and Molecular Toxicology
Published
2026-04-01
DOI
https://doi.org/10.1002/jbt.70799
Primary Topic
Curcumin's Biomedical Applications
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article
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article

Curcumin: Promising Modulator of Hypoxia Signaling in Cancer

Seema Ramniwas, Shubham Adhikari, Isha Rani, Tejveer Singh et al.
Journal of Biochemical and Molecular Toxicology
Curcumin's Biomedical Applications
article

Curcumin: Promising Modulator of Hypoxia Signaling in Cancer

Seema Ramniwas, Shubham Adhikari, Isha Rani, Tejveer Singh, Shafiul Haque, Diwakar Aggarwal, Jagjit Kaur, Darin Mansor Mathkor, Hardeep Singh Tuli, Sreeharsh Kuniyil, Deepika Sharma, Ginpreet Kaur
article en

Abstract

Solid tumors are widely known for having hypoxia, which promotes the growth and metastasis of the tumor. It is crucial for research and medicine to comprehend the diverse strategies by which cells sense oxygen and preserve oxygen homeostasis. A rising number of drugs have been found to block hypoxia function through various molecular pathways. For instance, curcumin, a naturally occurring polyphenolic chemical, has the ability to alter the tumor microenvironment and significantly influence the course of malignancy. Studies revealed that curcumin inhibits the signaling pathways including PI3K/Akt, AMPK-mTOR, and NF-κB, which are key factors in preventing hypoxia-induced cancer spread. In this article, we have discussed about the potential use of curcumin as a promising inhibitor of the molecular targets essential for hypoxia cell survival. Therefore, curcumin with strong anticancer effects could work well as a tumor-static drug in chemoprevention by inactivating hypoxia.

Journal of Biochemical and Molecular ToxicologyVol. 40(4)
Chandigarh University (IN), University of Delhi (IN), Maharishi Markandeshwar University, Mullana (IN), Narsee Monjee Institute of Management Studies (IN), Universidad Espíritu Santo (EC), ARC Centre of Excellence in Advanced Molecular Imaging (AU), Jazan University (SA)
Good health and well-being
Openalex Percentile: Top 22%
Curcumin's Biomedical Applications
DOISourceOpenAlex
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Curcumin: Promising Modulator of Hypoxia Signaling in Cancer — Seema Ramniwas, Shubham Adhikari, et al. · Journal of Biochemical and Molecular Toxicology (2026) | TGRS Research Map | TGRS