Intrauterine exposure to glyphosate-based herbicide during pregnancy induces testicular impairment via activating ferroptosis in offspring
indicated that at a 100 mg/kg GBH treatment caused testicular ferroptosis. Conversely, dietary supplementation with betaine appears to inhibit ferroptosis by modulating the expression of ferritin light chain (FTL), acyl-coenzyme A (CoA) synthetase long-chain family member 4 (ACSL4), and ferritin, thereby promoting testosterone synthesis and enhancing testicular development to some extent. In conclusion, these findings enhance our understanding of the risks associated with fetal testicular exposure to GBH in pregnant women and elucidate the protective mechanisms of betaine against GBH poisoning.
Authors
- Baoming Shi (ORCID: https://orcid.org/0000-0001-8560-4564)
- Guangdong Bai (ORCID: https://orcid.org/0009-0002-5820-1633)
- Ruiqi Wang (ORCID: https://orcid.org/0000-0002-9403-7693)
- Huan Yuan (ORCID: https://orcid.org/0000-0003-3433-7333)
- Wei He (ORCID: https://orcid.org/0000-0002-4272-2891)
- Teng Teng (ORCID: https://orcid.org/0009-0001-6018-656X)
- Yilin Bai
Institutions
- Southwest University (CN)
- Northeast Agricultural University (CN)
- Guangdong Academy of Agricultural Sciences (CN)
- Ministry of Agriculture (ID)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1016/j.ecoenv.2026.120123
- Primary Topic
- Pesticide and Herbicide Environmental Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National University's Basic Research Foundation of China