Endometrial NCOR1 deficiency contributes to implantation failure in endometriosis-associated infertility
), we demonstrate that NCOR1 loss is associated with increased ectopic lesion burden, implantation failure, defective decidualization, and severe subfertility, despite normal ovarian hormone production. NCOR1 deficiency was associated with disrupted progesterone-responsive signaling and endometrial receptivity. Together, these findings identify NCOR1 as an important regulator of endometrial function during early pregnancy and support an association between reduced NCOR1 expression and endometriosis-associated infertility.
Authors
- Johan Auwerx (ORCID: https://orcid.org/0000-0002-5065-5393)
- Loan Thi Kim Nguyen (ORCID: https://orcid.org/0000-0003-3799-0514)
- Jung‐Yoon Yoo (ORCID: https://orcid.org/0000-0001-9366-3863)
- Dinh Nam Tran (ORCID: https://orcid.org/0000-0002-8278-1386)
- Steven L. Young (ORCID: https://orcid.org/0000-0002-5205-4495)
- Ripla Arora
- Bruce A. Lessey
- Harini Raghu Kumar
- Jae-Wook Jeong (ORCID: https://orcid.org/0000-0002-5368-6478)
Institutions
- Atrium Health Wake Forest Baptist (US)
- Duke University (US)
- Yonsei University (KR)
- University of Missouri Health System (US)
- Duke University Health System (US)
- École Polytechnique Fédérale de Lausanne (CH)
- Michigan State University (US)
Publication Details
- Journal
- iScience
- Published
- 2026-04-12
- DOI
- https://doi.org/10.1016/j.isci.2026.115727
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Eunice Kennedy Shriver National Institute of Child Health and Human Development