Enhancing exosomes efficacy with engineered nanozymes for a multi-targeted combination strategy in osteoarthritis treatment
/Gel). This formulation significantly reduced inflammation, chondrocyte ferroptosis, cartilage degeneration, and subchondral bone remodeling, ultimately slowing OA progression. With excellent biocompatibility, this innovative combinatorial therapeutic strategy represents a comprehensive approach for enhancing Exo efficacy in OA treatment with promising translational potential.
Authors
- Handi Li (ORCID: https://orcid.org/0000-0003-3192-1649)
- Zhengyi Ni
- Chenyue Xu (ORCID: https://orcid.org/0000-0002-8484-3181)
- Fei Wang (ORCID: https://orcid.org/0000-0002-4812-9394)
- Yanxin Liu
- Qi Wang
- Huijun Kang
- Yuhang Shi
- Xiaobo Chen
- Zeyu Liu
- Ziyi Li
- Lie Wu
Institutions
- Hebei Medical University (CN)
- University of California, Los Angeles (US)
- Humboldt-Universität zu Berlin (DE)
- Third Hospital of Hebei Medical University (CN)
- Affiliated Hospital of Hebei University (CN)
- Wuhan University of Science and Technology (CN)
Publication Details
- Journal
- Materials Today Bio
- Published
- 2026-04-12
- DOI
- https://doi.org/10.1016/j.mtbio.2026.103118
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hebei Province
- Hebei Provincial Department of Bureau of Science and Technology
- Hebei Medical University
- Hebei Province Science and Technology Support Program
- Hebei Province Graduate Innovation Funding Project