Structural determinants of endopilus assembly, stability and functional specificity in bacterial type II secretion
assays, allowed us to identify the molecular determinants of secretion specificity and endopilus stability. These findings demonstrate how subtle sequence variations in conserved nanomachines have evolved to optimize their function and adapt to their local environments.
Authors
- Vladimir E. Shevchik (ORCID: https://orcid.org/0000-0002-8031-8638)
- Olivera Francetić (ORCID: https://orcid.org/0000-0002-4145-5314)
- Régine Dazzoni (ORCID: https://orcid.org/0000-0003-4666-5617)
- Edward H. Egelman (ORCID: https://orcid.org/0000-0003-4844-5212)
- Michaël Nilges (ORCID: https://orcid.org/0000-0002-1451-8092)
- Benjamin Bardiaux (ORCID: https://orcid.org/0000-0003-4014-9195)
- Ravi R. Sonani (ORCID: https://orcid.org/0000-0002-6212-2869)
- Matthijn Vos (ORCID: https://orcid.org/0000-0002-6046-9949)
- Theis Jacobsen
- Nadia Izadi-Pruneyre
- Stefaniia Ivashchenko
- Maylis Lejeune
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- Laboratoire de Microbiologie, Adaptation et Pathogénie (FR)
- Institut National des Sciences Appliquées de Lyon (FR)
- University of Virginia (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-12
- DOI
- https://doi.org/10.64898/2026.04.10.717868
- Primary Topic
- Bacterial Genetics and Biotechnology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche