Limonene and its metabolite perillyl alcohol inhibit Chlamydia trachomatis growth by altering host isoprenoid metabolism
) than the parent compound limonene. The antichlamydial activity of both limonene and perillyl alcohol was suppressed when infected cultures were supplemented with farnesyl or geranylgeranyl, indicating that the antichlamydial mechanism of the two monoterpenes involves competitive inhibition of protein prenylation. Hence, targeting host protein prenylation may be an effective antichlamydial strategy.
Authors
- Leena Hanski (ORCID: https://orcid.org/0000-0002-3121-8542)
- Maarit Ylätalo (ORCID: https://orcid.org/0000-0002-1552-5956)
- Inés Reigada (ORCID: https://orcid.org/0000-0003-4799-2011)
- Pilar Cebollada
- Candela Gerediaga
- Víctor López
Institutions
- University of Helsinki (FI)
- Universidad San Jorge (ES)
- Centro de Investigación y Tecnología Agroalimentaria de Aragón (ES)
Publication Details
- Journal
- Natural Products and Bioprospecting
- Published
- 2026-04-13
- DOI
- https://doi.org/10.1007/s13659-026-00611-5
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Helsingin Yliopisto
- Universidad San Jorge
- Gobierno de Aragón