Vogt–Koyanagi–Harada disease recurrence after laser treatment: A case report

This study reports two cases of Vogt-Koyanagi-Harada disease recurrence after laser treatment. Case 1 involved a woman in her late 70s with Vogt-Koyanagi-Harada disease that was controlled by adalimumab and steroid eye solution therapy. She presented with uveitis recurrence 4 weeks after undergoing neodymium:yttrium aluminum garnet laser posterior capsulotomy in both eyes. She was immediately treated with sub-Tenon triamcinolone acetonide injection in both eyes, which provided palliative relief. During the following year, she experienced further recurrences every 3-5 months. Case 2 involved a woman in her 40s with Vogt-Koyanagi-Harada disease and untreated type 2 diabetes. She had undergone pulse steroid therapy 3 months ago. She was prescribed insulin and oral diabetic medicine. The sudden glycemic control caused progression of her diabetic retinopathy, which was treated with retinal photocoagulation of the left eye. Three days later, there was recurrence of bilateral serous retinal detachment. She was immediately treated with sub-Tenon triamcinolone acetonide injection in both eyes, which improved serous detachment. Additional retinal photocoagulation was performed in both eyes 18 months later. These cases suggest that laser treatment triggers recurrence of Vogt-Koyanagi-Harada disease. Further investigation of this association is warranted.