Regulator-derived growth and fitness costs of <i>Salmonella</i> SPI-2 expression are environment specific and T3SS independent
, rather than its primary downstream virulence gene targets. These results demonstrate that SPI-2 expression is coupled to context specific cell growth and fitness deficits induced by its master regulator, offering a potential benefit to heterogeneous expression.
Authors
- Keara Lane (ORCID: https://orcid.org/0000-0002-8737-0455)
- Madison R. Spratt (ORCID: https://orcid.org/0000-0002-7925-6484)
- Cece Stumpf
- Mia Vigil
- Karen Snyder
Institutions
- Northwestern University (US)
- University of Chicago (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-11
- DOI
- https://doi.org/10.64898/2026.04.10.717833
- Primary Topic
- Salmonella and Campylobacter epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00