Clinical Value of HS-CRP, D-dimer and FIB Combined Detection in Diagnosis and Prognostic Health Evaluation of Lower Extremity Deep Venous Thrombosis

The purpose of this paper is to evaluate the diagnostic accuracy of High Sensitivity- C Reactive Protein (HS-CRP), D-dimer, and Fibrinogen (FIB) for diagnosing DVT. A total of 515 patients were included in the study, among which 67 cases were confirmed as DVT-positive based on diagnostic evaluation, providing a reliable sample size for assessing biomarker performance. This study primarily focuses on evaluating diagnostic performance, while also exploring the prognostic relevance of these biomarkers in relation to disease severity and progression, where the primary endpoint is defined as the detection accuracy of DVT based on biomarker positivity across the study groups, and secondary observations include associations between biomarker levels and extent of thrombus involvement. Patients with DVT who had been diagnosed and treated at the hospital were first recruited as research participants and split into three groups. Group 1 was diagnosing with HS-CRP test, group 2 diagnosing with D-dimer test and group 3 diagnosing with FIB test. Statistical analysis techniques such as the independent t-test and Logistic regression analysis were used to examine the detection rate. The data show that the efficacies of HS-CRP, D-dimer, and FIB for diagnosing DVT seem to be promising right now. DVT is one of the most prevalent symptoms of venous thromboembolism, and new investigations have shown that spine injuries, lower leg injuries, and physical trauma to the abdomen are all independent risk factors. Authors found that FIB and Hs-CRP are probable indicators of DVT in ankle fracture victims. DVT may develop in people with an elevated FIB, hs-CRP, fibrinogen, and high-energy damage, which are all independent risk factors.