A potential multimodal biomarker – cognitive signature associated with the conversion from subjective cognitive decline to mild cognitive impairment

INTRODUCTION: The disruption of key mechanisms involved in amyloid beta (Aβ) clearance during the early stages of dementia may contribute to the progression of cognitive decline toward irreversible brain damage. In this study, we investigated multiple immune-related pathways implicated in the management and clearance of Aβ within circulating extracellular vesicles (cEVs) and serum from individuals with subjective cognitive decline (SCD) who later progressed to mild cognitive impairment (MCI). METHODS: ε4 allele status, and the likelihood of conversion to MCI. RESULTS: with the Rey Auditory Verbal Learning Test (RAVLT) cognitive scores provided an excellent classification for SCD converted to MCI up to 2 years prior to clinical diagnosis. DISCUSSION: concentrations into a multimodal biomarker panel for longitudinal monitoring of progressive neurocognitive impairment.