A timeline of tau-mediated synaptotoxicity
Oligomeric tau has been increasingly implicated in synaptic impairments observed in Alzheimer's disease. In a recent study, Pareja-Navarro and colleagues provide insights into the precise timeline of synaptic deficits induced by oligomeric forms of tau. Such knowledge could aid in the design of therapeutic interventions to prevent synaptic loss.
Authors
- Claire S. Durrant (ORCID: https://orcid.org/0000-0001-7552-7358)
- Calum Bonthron
Institutions
- UK Dementia Research Institute (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Trends in Neurosciences
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.tins.2026.03.011
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- UK Research and Innovation
- James Dyson Foundation