Effects of perioperative fluid management on Glycocalyx injury in major urological oncology surgeries: a genetics and bioinformatics based approach

BACKGROUND: (hyaluronan synthase-2), were examined. METHODS: < 0.05. RESULTS: > 0.05). The observed transcriptomic pattern is biologically compatible with the hypothesis that liberal fluid loading may influence SDC1 dynamics through NPPA-related signaling; however, this interpretation remains hypothesis-generating because the primary randomized between-group comparison was not statistically significant. CONCLUSION: upregulation suggests a transcriptional-level stress/damage response affecting glycocalyx integrity. These findings suggest that genetic readouts (NPPA-SDC1 and exploratory HPSE/HAS2) may be useful for perioperative monitoring and generate hypotheses for further studies integrating multi-timepoint protein/ectodomain measurements. TRIAL REGISTRATION: This study registered at clinicaltrials. gov (NCT04780490).