Studies on a Sulfoxide-Bridged Tn Antigen Mimetic: Interaction with Macrophage Galactose Lectin and Inhibition of Sialyltransferase ST6GALNAC1
act as inhibitors of ST6GALNAC1representing, to the best of our knowledge, the first reported monosaccharide inhibitors of this enzyme. Although the inhibitory potency is modest, these compounds establish a valuable chemical starting point for targeting cancer-associated sialylation, an effort currently constrained by the lack of structural information for ST6GALNAC1.
Authors
- Filippo Rambaldi (ORCID: https://orcid.org/0009-0004-7168-2288)
- Fabio Dall’Olio (ORCID: https://orcid.org/0000-0001-9384-2845)
- Andrea Sodini (ORCID: https://orcid.org/0000-0002-0113-5797)
- Cristina Nativi (ORCID: https://orcid.org/0000-0002-6312-3230)
- Sandra J. van Vliet (ORCID: https://orcid.org/0000-0003-1811-2687)
- Filipa Marcelo (ORCID: https://orcid.org/0000-0001-5049-8511)
- Fabrizio Chiodo (ORCID: https://orcid.org/0000-0003-3619-9982)
- Emanuele Casali (ORCID: https://orcid.org/0000-0001-7501-5213)
- Maria Alejandra Travecedo
Institutions
- University of Pavia (IT)
- Amsterdam Neuroscience (NL)
- Norwegian Institute of Bioeconomy Research (NO)
- AgriBio (AU)
- Institute of Polymers, Composites and Biomaterials (IT)
- University of Florence (IT)
- Universidade Nova de Lisboa (PT)
- Vrije Universiteit Amsterdam (NL)
- University of Bologna (IT)
Publication Details
- Journal
- ACS Omega
- Published
- 2026-04-11
- DOI
- https://doi.org/10.1021/acsomega.6c00385
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Cooperation in Science and Technology
- Università degli Studi di Pavia
- Associazione Italiana per la Ricerca sul Cancro
- Applied Molecular Biosciences Unit
- Fundação para a Ciência e a Tecnologia