Metabolomic responses are more sensitive in muscle than serum following 28 days of arduous exercise with erythropoietin administration

, TT performance, blood volume and iron homeostasis. Four serum and 51 muscle metabolites were different (P ≤ 0.05, false discovery rate ≤ 0.10) at POST compared to PRE. Of the WGCNA networks identified, two serum modules were associated with aerobic performance (P = 0.05), while five skeletal muscle modules were associated with both aerobic performance and iron outcomes (P = 0.05). Changes to the serum and skeletal muscle metabolomes indicate altered carnitine, β-alanine and glucose metabolism metabolites, likely depicting a shift to greater fat oxidation, buffering capacity and the alteration in iron homeostasis following 28 days of EPO administration and strenuous exercise.

Authors

Institutions

Publication Details

Journal
Experimental Physiology
Published
2026-04-11
DOI
https://doi.org/10.1113/ep093342
Primary Topic
Erythropoietin and Anemia Treatment
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Metabolomic responses are more sensitive in muscle than serum following 28 days of arduous exercise with erythropoietin administration

Benjamin J. Ryan, David E Barney, Marques A. Wilson, Devin Drummer et al.
Experimental Physiology
Erythropoietin and Anemia Treatment
article

Metabolomic responses are more sensitive in muscle than serum following 28 days of arduous exercise with erythropoietin administration

Benjamin J. Ryan, David E Barney, Marques A. Wilson, Devin Drummer, Emily E. Howard, Nancy E. Murphy, Stefan M. Pasiakos, Jess A. Gwin, James P. McClung, Christopher T. Carrigan, Julie L. McNiff, Lee M. Margolis
article en

Abstract

, TT performance, blood volume and iron homeostasis. Four serum and 51 muscle metabolites were different (P ≤ 0.05, false discovery rate ≤ 0.10) at POST compared to PRE. Of the WGCNA networks identified, two serum modules were associated with aerobic performance (P = 0.05), while five skeletal muscle modules were associated with both aerobic performance and iron outcomes (P = 0.05). Changes to the serum and skeletal muscle metabolomes indicate altered carnitine, β-alanine and glucose metabolism metabolites, likely depicting a shift to greater fat oxidation, buffering capacity and the alteration in iron homeostasis following 28 days of EPO administration and strenuous exercise.

Experimental PhysiologyVol. 111(5)
Pennington Biomedical Research Center (US), U.S. Army Research Institute of Environmental Medicine (US), Oak Ridge Associated Universities (US), United States Army Combat Capabilities Development Command (US), United States Army (US), Oak Ridge Institute for Science and Education
U.S. Department of Energy, Oak Ridge Institute for Science and Education, Army Research Institute for the Behavioral and Social Sciences, U.S. Army Research Institute of Environmental Medicine, U.S. Army Medical Research and Development Command, Military Operational Medicine Research Program
Openalex Percentile: Top 24%
Erythropoietin and Anemia Treatment
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.