<i>In vivo</i> Wound Healing Effects of the Niosomal Formulations Containing <i>Narcissus tazetta</i> L. Bulb Extract
INTRODUCTION: bulb in an animal model. METHODS: bulbs and characterized pharmaceutically. Two niosomal (Span/Tween 40 with alcoholic plant extract and Span/Tween 60 with aqueous botanical extract lipid vesicles) creams and gels containing aqueous or alcoholic bulb extract were investigated in wound healing in male Wistar rats compared to Alpha® ointment. RESULTS: bulb extract, whether in cream or gel form, enhance wound healing by enabling advanced penetration of encapsulated herbal compounds. DISCUSSION: day, the wound surface area reduction of Alpha® ointment, free extract, and niosomal gel groups was significantly different from the control group. CONCLUSION: bulb has potential for pharmaceutical and cosmeceutical applications, which require further animal and clinical studies to determine the mechanism of action and potential side effects.
Authors
- Maryam Rameshk (ORCID: https://orcid.org/0000-0001-7093-8414)
- Abbas Pardakhty (ORCID: https://orcid.org/0000-0002-1848-5961)
- Jafar Ahmadi (ORCID: https://orcid.org/0000-0002-2709-9392)
- Elham Jafari (ORCID: https://orcid.org/0000-0001-9240-9177)
- Masoumeh Hakimi
- Fariba Sharififar (ORCID: https://orcid.org/0000-0002-9057-1987)
- Hossein Pardakhty
- Somayyeh Karami-Mohajeri
Institutions
- Islamic Azad University, Karaj (IR)
- Kerman University of Medical Sciences (IR)
Publication Details
- Journal
- Current Drug Delivery
- Published
- 2026-04-10
- DOI
- https://doi.org/10.2174/0115672018447717260126061154
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00