Pharmacokinetics of Bexagliflozin After Intravenous and Oral Administration in Cats

of 1780 ng/mL and a terminal half-life of 6.9 h. Absolute bioavailability was 78% (90% confidence interval: 73%-83%). Exposure was comparable between males and females after both routes (AUC ratios ~97%-103%). Treatments were well tolerated. These pharmacokinetic data indicate bexagliflozin exhibits rapid absorption, high oral bioavailability, and a half-life compatible with once-daily dosing in cats.