A Room-Temperature Rh-Catalyzed Kinetic Resolution Pathway for Expedient Access to <i>P</i> -Stereogenic Cyclic Phosphinates
-stereogenic five-membered rings. DFT calculations revealed that the proximal ligation of the phenolic additive plays a critical role in accelerating P-H bond activation, thereby enabling efficient hydrofunctionalization across the alkynyl segment. This method accommodates diverse substituents located at the phosphorus atom and the alkynyl moiety, providing a versatile platform for accessing valuable building blocks for pharmaceutical and chiral ligand design.
Authors
- Pui Ying Choy (ORCID: https://orcid.org/0000-0003-2765-0110)
- Fuk Yee Kwong (ORCID: https://orcid.org/0000-0001-9105-1740)
- Xiaolan Gu (ORCID: https://orcid.org/0009-0005-4227-6894)
- Xin-Yan Ke
- Shao-Fei Ni
Institutions
- Hong Kong Baptist University (HK)
- Chinese University of Hong Kong (HK)
- Shantou University (CN)
- Ji Hua Laboratory (CN)
- Key Laboratory of Guangdong Province (CN)
- State Key Laboratory of Synthetic Chemistry (CN)
Publication Details
- Journal
- JACS Au
- Published
- 2026-04-11
- DOI
- https://doi.org/10.1021/jacsau.6c00283
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hong Kong Baptist University
- National Natural Science Foundation of China
- Research Grants Council, University Grants Committee
- Chinese University of Hong Kong
- Basic and Applied Basic Research Foundation of Guangdong Province
- Songshan Lake Materials Laboratory