Revolutionizing Mg-based guided bone regeneration mesh derived from endogenous dentoalveolar bone augmentation

activated the PI3K/Akt pathway, significantly promoting endogenous bone regeneration. In beagle models, the mesh achieved effective repair of alveolar defects (15 mm × 8 mm × 5 mm) without extra collagen membranes or bone substitutes. It showed controlled degradation (92.16% volume retention at 4 weeks, >80% degradation at 12 weeks) and strong osteogenic capability (new bone volume fraction 86.89% at 12 weeks). Collectively, a promising GBR strategy with biodegradable LPBF Mg-alloy mesh to facilitate the alveolar bone regeneration is proposed.