The potential of plant-derived exosome-like nanovesicles from <i>Centella asiatica</i> leaves (CA-PDENs) for anti-inflammation and prevention of UVB-induced photoaging
AIMS: leaves (CA-PDENs) and evaluate their anti-inflammatory and anti-photoaging potential. MATERIALS & METHODS: was also evaluated. RESULTS: CA-PDENs are homogenous, spherical vesicles containing metabolite biosynthesis enzymes. They showed no cytotoxicity and were efficiently internalized. Functionally, CA-PDENs significantly suppressed nitric oxide production, indicating pronounced early-phase anti-inflammatory activity, while CD80, CD206, and interleukin-6 (IL-6) modulation showed consistent but non-significant trends. In fibroblasts, CA-PDENs exhibited strong antioxidant activity, reduced intracellular reactive oxygen species (ROS), attenuated collagen degradation, and enhanced wound closure. Moderate antibacterial activity was also observed. CONCLUSIONS: CA-PDENs possess robust anti-inflammatory and photoprotective properties, supporting their potential as multifunctional nanocosmetic ingredients.
Authors
- Anggraini Barlian (ORCID: https://orcid.org/0000-0002-0826-3134)
- Safira Meidina Nursatya (ORCID: https://orcid.org/0000-0001-5188-3542)
- Noviana Vanawati (ORCID: https://orcid.org/0000-0001-7569-253X)
- Yulia Rahmah (ORCID: https://orcid.org/0009-0007-4083-5351)
- Youngkwan Cho (ORCID: https://orcid.org/0009-0005-8565-113X)
- Annisa Nurrahmi Az Zahra (ORCID: https://orcid.org/0009-0000-1496-9080)
- Hanifa Azka Maulidisya (ORCID: https://orcid.org/0009-0002-1581-1191)
Institutions
- Bandung Institute of Technology (ID)
- Universitas Ahmad Dahlan (ID)
- Sultan Ageng Tirtayasa University (ID)
Publication Details
- Journal
- Future Science OA
- Published
- 2026-04-11
- DOI
- https://doi.org/10.1080/20565623.2026.2654777
- Primary Topic
- Medicinal Plants and Neuroprotection
- Type
- article
- Field-Weighted Citation Impact
- 0.00