Ameliorative Effects of Lycopene and L‐Carnitine on <scp>CCl</scp> <sub>4</sub> ‐Induced Liver Fibrosis Rat Model

≤ 0.001) and increased antioxidant enzyme activity of SOD (0.56 ± 0.04 U/dL) and CAT (0.489 ± 0.004 U/dL). Histological analysis showed a marked improvement in liver architecture, with reduced fibrosis appearance. These findings suggest that combination of Lyc and L-Car supplementation effectively counteracts fibrosis, oxidative stress, and liver enzymes elevation, supporting its potential role as a dietary therapeutic agent for metabolic and hepatic disorders. Future recommendations include conducting long- term clinical trials in humans to validate these findings, exploring optimal dosages for dietary lycopene supplementation, and investigating its molecular mechanisms of action.

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Publication Details

Journal
Food Science & Nutrition
Published
2026-04-01
DOI
https://doi.org/10.1002/fsn3.71689
Primary Topic
Drug-Induced Hepatotoxicity and Protection
Type
article
Field-Weighted Citation Impact
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article

Ameliorative Effects of Lycopene and L‐Carnitine on CCl 4 ‐Induced Liver Fibrosis Rat Model

Somia Shehzadi, Dr. Adeel Shahid, Moazzam Salamat, Sahar Shafiq et al.
Food Science & Nutrition
Drug-Induced Hepatotoxicity and Protection
article

Ameliorative Effects of Lycopene and L‐Carnitine on CCl 4 ‐Induced Liver Fibrosis Rat Model

Somia Shehzadi, Dr. Adeel Shahid, Moazzam Salamat, Sahar Shafiq, Zaid Talal Abdulqader Ali
article en

Abstract

≤ 0.001) and increased antioxidant enzyme activity of SOD (0.56 ± 0.04 U/dL) and CAT (0.489 ± 0.004 U/dL). Histological analysis showed a marked improvement in liver architecture, with reduced fibrosis appearance. These findings suggest that combination of Lyc and L-Car supplementation effectively counteracts fibrosis, oxidative stress, and liver enzymes elevation, supporting its potential role as a dietary therapeutic agent for metabolic and hepatic disorders. Future recommendations include conducting long- term clinical trials in humans to validate these findings, exploring optimal dosages for dietary lycopene supplementation, and investigating its molecular mechanisms of action.

Food Science & NutritionVol. 14(4)
University of Lahore (PK), Saba University (YE)
Openalex Percentile: Top 18%
Drug-Induced Hepatotoxicity and Protection
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