Ameliorative Effects of Lycopene and L‐Carnitine on <scp>CCl</scp> <sub>4</sub> ‐Induced Liver Fibrosis Rat Model
≤ 0.001) and increased antioxidant enzyme activity of SOD (0.56 ± 0.04 U/dL) and CAT (0.489 ± 0.004 U/dL). Histological analysis showed a marked improvement in liver architecture, with reduced fibrosis appearance. These findings suggest that combination of Lyc and L-Car supplementation effectively counteracts fibrosis, oxidative stress, and liver enzymes elevation, supporting its potential role as a dietary therapeutic agent for metabolic and hepatic disorders. Future recommendations include conducting long- term clinical trials in humans to validate these findings, exploring optimal dosages for dietary lycopene supplementation, and investigating its molecular mechanisms of action.
Authors
- Somia Shehzadi (ORCID: https://orcid.org/0009-0000-2721-9238)
- Dr. Adeel Shahid
- Moazzam Salamat
- Sahar Shafiq
- Zaid Talal Abdulqader Ali (ORCID: https://orcid.org/0009-0005-6582-6051)
Institutions
- University of Lahore (PK)
- Saba University (YE)
Publication Details
- Journal
- Food Science & Nutrition
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/fsn3.71689
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00