Deep visual proteomics uncovers nociceptor diversity and pain targets
. Indeed, overnight exposure of peptidergic nociceptors to NGF and a protein kinase C (PKC) activator produced functional sensitization associated with proteome changes. Functional knockdown experiments identified the up-regulated B3GNT2 enzyme as a potential effector of nociceptor sensitization. In summary, we present a high-resolution proteomic resource linking molecular identity to function, enabling the discovery of mechanisms underlying somatic sensation and pain sensitization.
Authors
- Wenhan Luo (ORCID: https://orcid.org/0000-0001-5202-8855)
- Gary R. Lewin (ORCID: https://orcid.org/0000-0002-2890-6352)
- Atena Shaterian Mohammadi (ORCID: https://orcid.org/0000-0003-0776-9624)
- Lin Wang (ORCID: https://orcid.org/0000-0002-8395-6184)
- Sampurna Chakrabarti (ORCID: https://orcid.org/0000-0002-2750-3877)
- Fabian Coscia (ORCID: https://orcid.org/0000-0002-2244-5081)
- Anuar Makhmut (ORCID: https://orcid.org/0009-0009-6913-4289)
Institutions
- Helmholtz Association of German Research Centres (DE)
- German Cancer Research Center (DE)
- Max Delbrück Center (DE)
- Helmholtz Centre for Infection Research (DE)
- German Centre for Cardiovascular Research (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-04-11
- DOI
- https://doi.org/10.1038/s41467-026-71418-8
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00