Toward a Fully Embodied Virtual Drosophila: Incorporating the Ventral Nerve Cord via Pinout Search

Eon Systems' virtual Drosophila uses the FlyWire brain connectome but interfaces with the body through animation controllers rather than the published ventral nerve cord (VNC) connectome. This design choice limits the model's embodiment by decoupling neural dynamics from motor output. This document outlines a search-based method to integrate the MANC VNC connectome by identifying the correct pinout mapping from descending neurons to VNC inputs. The approach is potentially tractable and represents a feasible next step toward a fully embodied virtual fly.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-04-11
DOI
https://doi.org/10.5281/zenodo.19511908
Primary Topic
Neurobiology and Insect Physiology Research
Type
article
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article

Toward a Fully Embodied Virtual Drosophila: Incorporating the Ventral Nerve Cord via Pinout Search

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Zenodo (CERN European Organization for Nuclear Research)
Neurobiology and Insect Physiology Research
article

Toward a Fully Embodied Virtual Drosophila: Incorporating the Ventral Nerve Cord via Pinout Search

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Abstract

Eon Systems' virtual Drosophila uses the FlyWire brain connectome but interfaces with the body through animation controllers rather than the published ventral nerve cord (VNC) connectome. This design choice limits the model's embodiment by decoupling neural dynamics from motor output. This document outlines a search-based method to integrate the MANC VNC connectome by identifying the correct pinout mapping from descending neurons to VNC inputs. The approach is potentially tractable and represents a feasible next step toward a fully embodied virtual fly.

Zenodo (CERN European Organization for Nuclear Research)
Openalex Percentile: Top 7%
Neurobiology and Insect Physiology Research
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