NCOA4-mediated ferritinophagy: emerging role and novel therapeutic target in precision oncology
: FTH1: ferritin heavy chain 1; GPX4: glutathione peroxidase 4; GSH: glutathione; HIF: hypoxia-inducible factor; LIP: labile iron pool; MAPK/JNK: mitogen-activated protein kinase; NCOA4: nuclear receptor coactivator 4; PUFAs: polyunsaturated fatty acids; SLC7A11: solute carrier family 7 member 11; TFRC: transferrin receptor; TFEB: transcription factor EB.
Authors
- Dengwang Chen (ORCID: https://orcid.org/0009-0004-5120-8802)
- Tao Duan (ORCID: https://orcid.org/0000-0001-5320-4611)
- Xin Wang (ORCID: https://orcid.org/0000-0002-5122-2418)
- Jinyan Zhang
- Xinyue Jiang
- Ying Tian
Institutions
- Chinese University of Hong Kong (HK)
- Zunyi Medical University (CN)
- Guizhou Cancer Hospital (CN)
Publication Details
- Journal
- Autophagy
- Published
- 2026-04-11
- DOI
- https://doi.org/10.1080/15548627.2026.2656779
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 21.88