Pan-cancer macrophage atlas uncovers that MHC-IIhigh TAMs induce Treg activation through physical interactions
TAMs correlates with immunotherapy resistance. Together, these findings redefine macrophage antigen presentation in the TME and reveal new therapeutic opportunities.
Authors
- Xun Lan (ORCID: https://orcid.org/0000-0002-6523-046X)
- Yibo Gao (ORCID: https://orcid.org/0000-0002-0501-9814)
- Wei Wang (ORCID: https://orcid.org/0000-0002-6810-9518)
- Naixue Yang (ORCID: https://orcid.org/0000-0002-0705-7611)
- Xinquan Liu
- Hao Yuan
- Chang Liu
- Yue Li
- Yi Yao
- Mingchao Wang
- Xin Lin (ORCID: https://orcid.org/0000-0003-0956-3654)
Institutions
- Qingdao University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Kunming Medical University (CN)
- Peking Union Medical College Hospital (CN)
- Chinese PLA General Hospital (CN)
- Yuhuangding Hospital (CN)
- Center for Life Sciences (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Cell Reports
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.celrep.2026.117230
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality