Origin of the ionic-strength dependent reentrant behavior in the liquid-liquid phase separation of uncharged intrinsically disordered proteins
] is due to the entropy-driven crowding, and the ion concentration inside the condensate is lower than in the bulk. Our study unravels a general physical mechanism of salt-dependent reentrant behavior in LLPS in uncharged IDPs.
Authors
- Sayantan Mondal (ORCID: https://orcid.org/0000-0002-4612-7758)
- Eugene I. Shakhnovich (ORCID: https://orcid.org/0000-0002-4769-2265)
Institutions
- Harvard University (US)
- Harvard University Press (US)
Publication Details
- Journal
- Communications Chemistry
- Published
- 2026-04-11
- DOI
- https://doi.org/10.1038/s42004-026-02011-9
- Primary Topic
- Polymer Surface Interaction Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Harvard University