Application of machine learning in osteoporosis screening: a narrative review

Machine learning has the potential to address limitations of traditional osteoporosis screening through advanced data processing and pattern recognition capabilities. This review provides a critical analysis of ML applications in opportunistic screening, precision risk assessment, and quantitative bone quality analysis, while addressing current implementation challenges and future research directions to enhance early diagnosis, reduce fracture risk, and improve patient outcomes. As a narrative synthesis, this review highlights strategic directions and translational challenges rather than providing a systematic appraisal of evidence. Machine learning offers promising approaches to address the limitations of traditional osteoporosis screening.

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Publication Details

Journal
npj Digital Medicine
Published
2026-04-11
DOI
https://doi.org/10.1038/s41746-026-02516-6
Primary Topic
Bone health and osteoporosis research
Type
article
Field-Weighted Citation Impact
0.00

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article

Application of machine learning in osteoporosis screening: a narrative review

Huanbing Liu, Siying Zhang, Guohui Hu, Xueting Shen et al.
npj Digital Medicine
Bone health and osteoporosis research
article

Application of machine learning in osteoporosis screening: a narrative review

Huanbing Liu, Siying Zhang, Guohui Hu, Xueting Shen, Shu Wang, Jin Xiong
article en

Abstract

Machine learning has the potential to address limitations of traditional osteoporosis screening through advanced data processing and pattern recognition capabilities. This review provides a critical analysis of ML applications in opportunistic screening, precision risk assessment, and quantitative bone quality analysis, while addressing current implementation challenges and future research directions to enhance early diagnosis, reduce fracture risk, and improve patient outcomes. As a narrative synthesis, this review highlights strategic directions and translational challenges rather than providing a systematic appraisal of evidence. Machine learning offers promising approaches to address the limitations of traditional osteoporosis screening.

npj Digital Medicine
Nanchang University (CN), First Affiliated Hospital of Nanchang University (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 6%
Bone health and osteoporosis research
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