Astrocytic frataxin deficiency drives neurocognitive impairment in sickle cell mice
mice exhibited impaired cognitive function assessed by the functional novel object recognition (NOR) tests. Induction of FXN improved cognitive responses in the SS mice. Overall, our data demonstrate that astrocytic FXN plays a pivotal role in regulating neuroaxonal health and cognitive function in SCD.
Authors
- Samit Ghosh (ORCID: https://orcid.org/0000-0002-3536-3077)
- Enrico M. Novelli (ORCID: https://orcid.org/0000-0003-3010-8285)
- Lesley May Foley
- Stephen Y. Chan (ORCID: https://orcid.org/0000-0002-9520-7527)
- Paritosh Mondal (ORCID: https://orcid.org/0000-0002-2608-6645)
- Rimi Hazra (ORCID: https://orcid.org/0000-0003-2390-0071)
- Shane C Lenhart
- Hong Wang (ORCID: https://orcid.org/0000-0003-0477-2908)
- Nandinii Sekar (ORCID: https://orcid.org/0009-0008-2827-3138)
- T Kevin Hitchens
Institutions
- University of Pittsburgh (US)
Publication Details
- Journal
- PNAS Nexus
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1093/pnasnexus/pgag106
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Neurological Disorders and Stroke