Use of Pentoxifylline to Improve Seminal Parameters in Dogs

OBJECTIVE: The study aimed to evaluate the effect of a one-shot oral administration of pentoxifylline on semen parameters in normospermic and oligospermic dogs. METHODS: Twenty-nine dogs were categorized as normospermic or oligospermic based on baseline sperm concentration. After 10 days from the first semen evaluation, each dog received 10 mg/kg of pentoxifylline orally, given 40 min prior to ejaculation. Semen was evaluated using a Computer-Assisted Sperm Analysis (CASA) system and Eosin-Nigrosin staining for vitality. RESULTS: Compared with baseline, pentoxifylline treatment resulted in a statistically significant increase in sperm concentration and progressive motility (p < 0.01), most notably in oligospermic dogs. CONCLUSION AND CLINICAL SIGNIFICANCE: These findings highlight the beneficial effects of pentoxifylline and confirm its potential as an adjunct therapy for improving semen quality in subfertile male dogs.