Mechanism and clinical application of ozone therapy in treating skin ulcer diseases

Ozone therapy not only has antibacterial effects but also has a series of biological effects. It can stimulate the production of antioxidant enzymes, increase the elasticity of red blood cell membranes, improve blood flow and tissue oxygenation, promote the release of growth factors, and activate cell metabolism and immune function. Through multi-target regulation, ozone therapy has shown significant efficacy in treating skin ulcer diseases such as diabetic foot ulcers and burns, with overall controllable safety. Currently, most research on ozone therapy focuses on the correlation between the ozone concentration and therapeutic efficacy. This review provides a systematic review of the mechanism and clinical research progress of ozone therapy in treating skin ulcer diseases. While ozone therapy has demonstrated notable effectiveness in treating diabetic foot ulcers and other conditions, more rigorous clinical research is necessary to refine treatment plans and create standard guidelines for its use. In the future, the integration of ozone therapy with precision medicine and innovative delivery methods could broaden its application in treating skin ulcer diseases. JOURNAL/mgres/04.03/01612956-990000000-00090/figure1/v/2026-04-13T130436Z/r/image-tiff.