Calcium isotope ratio (δ44/42Ca) reflects kidney function and calcium excretion but not bone mineral density or bone turnover: a cross-sectional study
Ca) in isolated bone diseases are limited. Previously proposed as a diagnostic marker in metabolic bone disorders, we now extend our findings from monogenic bone diseases to patients with osteoporosis and osteopenia. METHODS: Ca were analyzed alongside bone (such as bone density) and treatment parameters. RESULTS: Ca stratification showed higher urinary calcium and PTH (both p<0.0001) in individuals above the threshold, a pattern consistent with neutral or positive bone mineral balance. CONCLUSION: Ca can contribute to individualized diagnostics and treatment monitoring in bone disease.
Authors
- Felix N. Schmidt (ORCID: https://orcid.org/0000-0001-6586-6794)
- Florian Barvencik (ORCID: https://orcid.org/0000-0002-0200-8431)
- Mikolaj Bartosik (ORCID: https://orcid.org/0000-0002-9094-6021)
- Ralf Oheim (ORCID: https://orcid.org/0000-0001-9449-5013)
- Robert Munzinger (ORCID: https://orcid.org/0009-0007-3114-484X)
- Michael Amling
- Thorsten Schinke
Institutions
- Universität Hamburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
Publication Details
- Journal
- Osteoporosis International
- Published
- 2026-04-11
- DOI
- https://doi.org/10.1007/s00198-026-07935-5
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00