Embryonic sheep placenta alleviates muscle-fat wasting symptoms and improves gut microbiome dysbiosis in cachexia mice

< 0.05) fat mass. Western blot shows that ESP downregulates the expression of TRIM63 and inhibits the expression of the HSL protein in the AMPK signaling pathway. Integrated multi-omics analysis suggests that ESP reshapes the gut microbiota structure of cachexia mice, restores their gut homeostasis and improves energy metabolism pathways. In conclusion, ESP plays a protective role in cachexia mice by alleviating the symptoms of muscle-fat atrophy, maintaining gut homeostasis and improving energy metabolism pathway.