HERC1 oncogene enhances stemness and tumorigenic potential in CD44+-derived organoids of head and neck squamous cell carcinoma through IL-6/STAT3 signaling
tumor-stromal crosstalk. Targeting HERC1 may offer a promising strategy to eliminate cancer stem-like cells in HNSCC.
Authors
- Kang Pa Lee (ORCID: https://orcid.org/0000-0002-6136-4970)
- Hong Sook Kim (ORCID: https://orcid.org/0000-0003-0971-0853)
- Jamin Ku
- Sei Young Lee (ORCID: https://orcid.org/0000-0001-6034-6386)
- Jangok Yeo
- Eunjin Jeong
- Hajeong Kim
- Seo Lyn Choi (ORCID: https://orcid.org/0009-0009-7681-0572)
- Hye Lin Kim
- Haeun Kim (ORCID: https://orcid.org/0009-0001-5599-4327)
- Chang-Whan Yoon (ORCID: https://orcid.org/0009-0009-5940-3430)
- Suji Baek
- Seok-Hyung Kim
- Jeong-Yoon Yang
- Seohee Park
- Jae Kyeong Lee
- Jung Ho Park
- Sang-Hyuk Lee
- Seojin Jang
Institutions
- Mando Corporation (South Korea) (KR)
- Eulji University (KR)
- Samsung (South Korea) (KR)
- Samsung Medical Center (KR)
- Kangbuk Samsung Hospital (KR)
- Daejeon Eulji Medical Center, Eulji University (KR)
- Chung-Ang University Hospital (KR)
- Osong Medical Innovation Foundation (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Oncogene
- Published
- 2026-04-11
- DOI
- https://doi.org/10.1038/s41388-026-03725-9
- Primary Topic
- Skin and Cellular Biology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Sungkyunkwan University
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- Samsung