A Critical Review of Analytical Methods for Rocuronium Quantification: Comparative Evaluation of Eco-Friendliness, Applicability and Performance

AGREE) to evaluate the greenness, Blueness Assessment Graphical Index (BAGI) to assess the applicability of the method (blueness), and Red Analytical Performance Index (RAPI) for the analytical performance (redness). Finally, the Red-Green-Blue model (RGB-12 algorithm) and Multi-Color Assessment (MA) Tool were employed, which provide a unified "whiteness score" which reflects the degree of sustainability of the method. By evaluating the strengths, limitations, eco-friendliness, applicability, innovation, performance and sustainability of the reported methods, this review establishes a novel, comprehensive framework to guide decision-making in analytical method selection and development.