Multi-omics and electrophysiological examination of GABAA receptors in the dorsolateral prefrontal cortex of humans with alcohol use disorder
Rs in AUD, higher levels of GABRG1 and significant decrease of mitochondrial transcripts in AUD individuals. Notably, transcriptional differences were gradually lost as the analysis moved from transcription to protein and function within our cohort. This suggests post-translational buffering in AUD resulting in unchanged GABA receptor synaptic activity. Our novel findings establish a proof of concept for reactivating AUD post-synaptic receptors and integrating this information with multiple levels of multi-omic analyses, as well as outline hypothesis-generating insights into this multifaceted disease.
Authors
- William K. Russell (ORCID: https://orcid.org/0000-0003-1931-4555)
- Antônio Lúcio Teixeira (ORCID: https://orcid.org/0000-0002-9621-5422)
- Thomas D. Meyer (ORCID: https://orcid.org/0000-0003-4236-7778)
- Laura Stertz (ORCID: https://orcid.org/0000-0002-1426-6796)
- Gabriel R. Fries (ORCID: https://orcid.org/0000-0002-5468-2612)
- Pietro Scaduto (ORCID: https://orcid.org/0000-0001-8197-615X)
- Agenor Limón (ORCID: https://orcid.org/0000-0002-6613-770X)
- Consuelo Walss-Bass
- Julia Granchi
- B. Salameh
- B. Miller
Institutions
- The University of Texas Medical Branch at Galveston (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Molecular Psychiatry
- Published
- 2026-04-11
- DOI
- https://doi.org/10.1038/s41380-026-03598-0
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Prevention and Research Institute of Texas
- John S. Dunn Foundation
- National Institute on Aging