Corneal Targeted Mucoadhesive Emulsion for Prolonged Delivery of Voriconazole: Formulation Evaluation and Pharmacokinetic Assessment
values of 9.66 ± 3.49 μg/mL (marketed), 10.47 ± 6.43 μg/mL (VE-3), and a four-folds higher 41.67 ± 28.48 μg/mL for CS-VE-3, indicating prolonged corneal contact with chitosan incorporation. Ocular irritation studies confirmed safety and tolerability. The optimized mucoadhesive emulsion offers a promising strategy for sustained ocular delivery of voriconazole, potentially improving therapeutic outcomes in FK management.
Authors
- Rabi Sankar Bhatta (ORCID: https://orcid.org/0000-0003-4844-2388)
- S. K. Srivastava (ORCID: https://orcid.org/0000-0001-8237-9189)
- Sachin Nashik Sanap (ORCID: https://orcid.org/0000-0002-1427-9247)
- Sristi Agrawal (ORCID: https://orcid.org/0009-0008-4656-131X)
- Amol Chhatrapati Bisen (ORCID: https://orcid.org/0000-0003-4841-0140)
- Arpon Biswas (ORCID: https://orcid.org/0000-0002-3755-407X)
Institutions
- Central Drug Research Institute (IN)
- National Institute of Nutrition (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Biopharmaceutics & Drug Disposition
- Published
- 2026-04-11
- DOI
- https://doi.org/10.1002/bdd.70028
- Citations
- 1
- Primary Topic
- Advanced Drug Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 14.92