Unlocking caspase-8 enables Pt(IV) to trigger robust caspase-3/GSDME-mediated pyroptosis via drug co-delivery in chemoresistant bladder cancer
T lymphocyte infiltration. Consequently, when combined with an αPD-L1 antibody, this strategy effectively eradicated GP-R bladder tumors and suppressed recurrence in vivo, demonstrating compelling translational potential. In summary, our work presents a translatable nanotherapeutic strategy that resensitizes GP-R MIBC to chemo-immunotherapy by leveraging a synergistic "unlock-and-trigger" mechanism to reactivate pyroptosis.
Authors
- Hanchen Zhang (ORCID: https://orcid.org/0000-0003-0498-429X)
- Baotong Zhou
- Haihua Xiao
- Bo Ge (ORCID: https://orcid.org/0000-0003-1184-1510)
- Haiwei Hu (ORCID: https://orcid.org/0000-0001-6477-1662)
- Yongbo Tang (ORCID: https://orcid.org/0000-0002-2771-6020)
- Jintao Wen
Institutions
- Guilin Medical University (CN)
- Chinese Academy of Sciences (CN)
- Guangzhou Institutes of Biomedicine and Health (CN)
- Beijing National Laboratory for Molecular Sciences (CN)
- Institute of Chemistry (CN)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-04-12
- DOI
- https://doi.org/10.1186/s12951-026-04449-4
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guangxi Zhuang Autonomous Region
- National Natural Science Foundation of China
- Guilin Scientific Research and Technology Development Plan
- Guangxi Key Research and Development Program