CA19-9 promotes liver metastasis of pancreatic cancer through E-selectin mediated extravasation
. Therapeutic targeting of CA19-9 with a neutralizing antibody markedly reduced liver metastatic burden after metastatic seeding. CA19-9 expression increased AKT signaling in PDAC cells and liver metastases, and CA19-9 levels correlated with AKT activation in human PDAC tissues. These findings show that CA19-9 promotes PDAC liver metastasis through E-selectin-dependent metastatic seeding and AKT-associated metastatic outgrowth, highlighting CA19-9 as a functional mediator of PDAC metastasis and a potential therapeutic target.
Authors
- Jasper Hsu (ORCID: https://orcid.org/0000-0001-8576-1957)
- Kathryn Lande (ORCID: https://orcid.org/0009-0005-1613-8981)
- Kristina Peck
- Hervé Tiriac (ORCID: https://orcid.org/0000-0001-5039-6750)
- Jacob R. Tremblay (ORCID: https://orcid.org/0000-0003-1818-7953)
- Jingjing Zou (ORCID: https://orcid.org/0000-0002-4749-105X)
- Hyemin Song
- Vasiliki Pantazopoulou (ORCID: https://orcid.org/0000-0002-5965-5795)
- Victoria Osorio-Vasquez (ORCID: https://orcid.org/0000-0001-7956-1633)
- Dannielle D. Engle (ORCID: https://orcid.org/0000-0003-1876-7675)
- Casie S. Kubota (ORCID: https://orcid.org/0000-0003-2323-7409)
- Ronald M. Evans (ORCID: https://orcid.org/0000-0002-9986-5965)
- Michael Downes (ORCID: https://orcid.org/0000-0002-6351-9585)
- Jonathan Zhu (ORCID: https://orcid.org/0000-0001-7074-0459)
- Andrew M. Lowy (ORCID: https://orcid.org/0000-0002-7106-0735)
- Satoshi Ogawa (ORCID: https://orcid.org/0000-0003-4970-4212)
- Chelsea Bottomley
- Kassidy Curtis
- Ryan Tomita
- Sophie Keightley
- Yongjia Wang
Institutions
- Salk Institute for Biological Studies (US)
- University of California San Diego (US)
- Human Longevity (United States) (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-10
- DOI
- https://doi.org/10.64898/2026.04.08.717301
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Conrad Prebys Foundation
- Pancreatic Cancer Action Network
- Leona M. and Harry B. Helmsley Charitable Trust
- Emerald Foundation
- Paul M. Angell Family Foundation