Ruthenium Complexes of Atovaquone Acting on Multiple Stages of the <i>Plasmodium</i> Life Cycle
against asexual and sexual stages. Complexes were capable of blocking parasite transmission from humans to insects, and this was achieved for both gametocytes and oocyst stages, while ATV solely blocked oocysts. This is the first example of metal complexes inhibiting both asexual and sexual parasites with similar potency, broadly expanding the therapeutic utility of metalladrugs in medicinal chemistry.
Authors
- Aline de Sousa Santiago
- Stefanie Costa Pinto Lopes (ORCID: https://orcid.org/0000-0002-6981-2192)
- Nicoletta Basilico (ORCID: https://orcid.org/0000-0001-9030-1066)
- Caroline C. Sousa (ORCID: https://orcid.org/0000-0001-5641-8076)
- Camila Fabbri (ORCID: https://orcid.org/0009-0005-6017-6950)
- Rosa Amélia Gonçalves Santana (ORCID: https://orcid.org/0000-0001-6041-0392)
- Helenita Costa Quadros (ORCID: https://orcid.org/0000-0002-7191-4809)
- Diogo R. M. Moreira
- João Honorato de Araujo-Neto
- Sarah D’Alessandro
- Silvia Cássia B. Justiniano
- Pedro Henrique S. Marcon (ORCID: https://orcid.org/0000-0001-9950-1128)
- Dione D. Maciel de Menezes
- Larissa de Sena Lamar Nunes
Institutions
- University of Milan (IT)
- Fundação de Medicina Tropical (BR)
- Rede de Química e Tecnologia (PT)
- Hospital Universitário da Universidade de São Paulo (BR)
- Universitas Borobudur (ID)
- Fundação Oswaldo Cruz (BR)
- Universidade São Francisco (BR)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-11
- DOI
- https://doi.org/10.1021/acs.jmedchem.5c02978
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado do Amazonas
- Fundação Oswaldo Cruz