Acute fipronil toxicity in humans following intentional ingestion: a case report with favorable outcome from a resource-limited setting

Fipronil is N-phenylpyrazole insecticide which acts by inhibiting gamma‑aminobutyric acid type A gated chloride channels resulting in hyperexcitability of neurons. While its more selective for insect receptors, it can cause toxicity in humans if ingested. Only few literatures are available on this insecticide poisoning leading to adverse clinical presentation. we report the case of 35-year-old female who presented with vomiting and abdominal pain following deliberate ingestion of Fipronil. Upon presentation, the patient was fully conscious with blood pressure and heart rate within normal range. There was no sign of skin irritation, seizure, or neurologic deficit. Laboratory investigations including hemogram, renal function, liver function and electrolyte are within normal limit. The patient received supportive management and was discharged after two days of observation with favourable outcome. Fipronil poisoning is often asymptomatic; however, when symptoms occur, they primarily include vomiting, nausea, and seizures. The outcome is favourable. The mainstay of treatment is supportive treatment and seizure control. Given the availability of limited data, gastric lavage is not highly recommended.