STUB1-VCP/p97 limits PINK1 overaccumulation to safeguard mitophagy and memory
: AD, Alzheimer disease; CALCOCO2/NDP52, calcium binding and coiled-coil domain 2; MPP, mitochondrial processing peptidase; MQC, mitochondrial quality control; OMM, outer mitochondrial membrane; OPTN, optineurin; PARL, presenilin associated rhomboid like; PINK1, PTEN induced kinase 1; PRKN, parkin RBR E3 ubiquitin protein ligase; SILAC, stable isotope labeling by amino acids in cell culture; STUB1, STIP1 homology and U-box containing protein 1; TPR, tetratricopeptide repeat; VCP/p97, valosin containing protein; WIPI2, WD repeat domain, phosphoinositide interacting 2.
Authors
- Guang Xiu Lu (ORCID: https://orcid.org/0000-0002-2268-1033)
- Evandro Fei Fang (ORCID: https://orcid.org/0000-0003-0355-7202)
- Jin-Yi Lin
- Ze-Bo Huang
Institutions
- University of Oslo (NO)
- Akershus University Hospital (NO)
- NORCE Research AS (NO)
Publication Details
- Journal
- Autophagy
- Published
- 2026-04-11
- DOI
- https://doi.org/10.1080/15548627.2026.2658848
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Norges Forskningsråd
- Akershus Universitetssykehus
- Basic and Applied Basic Research Foundation of Guangdong Province