Salivary volatilome profiling in pediatric eosinophilic esophagitis: a pilot study on a non-invasive approach in clinical practice
-3-hexen-1-ol and 2-phenylethanol show a ubiquitous capability to discriminate EoE against different populations. Linear discriminant analysis (LDA) of the panel of 16 VOCs achieved 83.3% accuracy in classifying EoE vs. healthy controls, 81.2% accuracy in distinguishing EoE from GI controls, and 80.0% accuracy in classifying active vs. non-active EoE. Salivary VOC profiling enables accurate discrimination of pediatric EoE from controls and stratification by disease activity. This non-invasive approach holds promise as a diagnostic and monitoring tool in clinical practice, especially in children.
Authors
- Christian Barbato (ORCID: https://orcid.org/0000-0003-1737-9064)
- Alexandro Catini (ORCID: https://orcid.org/0000-0001-6050-2908)
- Rosamaria Capuano (ORCID: https://orcid.org/0000-0002-7811-0862)
- Carla Petrella (ORCID: https://orcid.org/0000-0003-0651-1816)
- Corrado Di Natale (ORCID: https://orcid.org/0000-0002-0543-4348)
- Antonio Minni (ORCID: https://orcid.org/0000-0002-3890-3665)
- Giulia D’Arcangelo (ORCID: https://orcid.org/0000-0001-9000-2584)
- Giusy Russo (ORCID: https://orcid.org/0000-0002-1443-1624)
- Salvatore Oliva
Institutions
- University of Rome Tor Vergata (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Ellis Hospital (US)
- Institute of Molecular Biology and Pathology (IT)
- SRM University (IN)
- Policlinico Tor Vergata (IT)
- Institute of Cell Biology and Neurobiology (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Life Medicine
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1093/lifemedi/lnag012
- Primary Topic
- Eosinophilic Esophagitis
- Type
- article
- Field-Weighted Citation Impact
- 0.00