Sulfur Ylide-Mediated Cascade Transformations to Access Cyclopropylallocolchicinoids with Potent Antimitotic Activity
-rich dibenzocycloheptanes, including enantiomerically enriched variants. Furthermore, we have demonstrated the synthetic utility of this protocol in preparing various advanced intermediates pertinent to natural product synthesis and medicinal chemistry. Comprehensive biological studies have identified a potent analogue that disrupts microtubule organization and dynamics, leading to mitotic arrest and the consequent attenuation of influenza A virus infection.
Authors
- Tejal Pathak
- Dipto Mukhopadhyay
- Kaushalendra Patel (ORCID: https://orcid.org/0009-0002-9083-4131)
- Indranil Banerjee (ORCID: https://orcid.org/0000-0002-0808-2392)
- Anwita Chattopadhyay (ORCID: https://orcid.org/0000-0003-1294-7552)
- Sripada S. V. Ramasastry (ORCID: https://orcid.org/0000-0001-5814-9092)
- S. C. Pal (ORCID: https://orcid.org/0009-0002-2702-0661)
Institutions
- Indian Institute of Science Education and Research Mohali (IN)
Publication Details
- Journal
- JACS Au
- Published
- 2026-04-11
- DOI
- https://doi.org/10.1021/jacsau.6c00268
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Biotechnology, Ministry of Science and Technology, India
- Indian Council of Medical Research
- Indian Institute of Science Education and Research Mohali